Let's take a minute to talk about your medication. This is hydrocortisone rectal cream. It is used to help treat itching or swelling caused by hemorrhoids or other inflammatory conditions in the rectum. It may have other uses, too. You should apply hydrocortisone rectal cream exactly as instructed by your doctor. Be sure to wash your hands before and after using this medication. When applying the cream, use only the applicator provided with the medication. If possible, avoid going the bathroom for at least one hours after using the cream. It is important to store the cream at room temperature away from moisture and heat. Most people tolerate this medicine well. The most common side effect is skin irritation. This can include burning, itching, and dryness. These effects are normal if they are mild and should go away. If these or other side effects become reasons you want to stop using this medicine, please talk to your doctor or pharmacist. As with any medicine, rare but more serious side effects can occur. You should read the Patient Information Sheet to know which symptoms to watch for and when to report changes. Hydrocortisone rectal cream can interact with other medicines. You should always check with your doctor or pharmacist before taking or using other medicines. Women should check with their doctors before using during pregnancy or breastfeeding. For best results with hydrocortisone rectal cream, be sure to follow the directions and call your doctor if your symptoms do not improve.