Let's take a minute to talk about your medication. This is estradiol extended release patches. Estradiol contains hormones called estrogens. It can help improve problems from menopause, like hot flashes, vaginal dryness and thinning bones. Estradiol has other uses, too, like replacing estrogen in women who don't make enough naturally. Estradiol patches are often applied to the skin one or two times each week. You should apply the patches exactly as directed by your doctor. Make sure the area on your body is clean, dry, and free of dirt and oil. The sticky side of the patch should be placed on the stomach or buttock. Do not place the patch on any part of your breasts. You should read the 'Instructions for Use' for full information. If you still have questions, your doctor or pharmacist can help. Most people tolerate this medicine well. Common side effects include headaches, breast pain, and vaginal bleeding or spotting. It can also cause stomach cramps, nausea, and irritation or redness at the application site. These effects are normal if they are mild and should go away. If these or other side effects become reasons you want to stop taking this medicine, please talk to your doctor or pharmacist. As with all medicines, rare but serious side effects can occur. Estradiol can cause conditions like heart attacks, stroke, blood clots, or dementia. It can also cause cancer of the breast, uterus or ovaries. To reduce the risk of these happening, you should work with your doctor to take the lowest dose for the shortest amount of time necessary to ease your symptoms. You should read the Patient Information Sheet to know which symptoms to watch for and when to report changes. Estradiol may interact with other medicines. You should check with your doctor or pharmacist before taking any new medicines. Also, estradiol should not be used in pregnant or breastfeeding women. For best results, work closely with your healthcare team to help manage side effects.