Let's take a minute to talk about your medication. This is Simponi, and you should administer it as directed by your doctor. Simponi is given as an injection under your skin. Before using Simponi at home, you should demonstrate an injection to your health care provider. This will help you feel confident doing it on your own. You should also know how to dispose of needles. If you have any questions, your doctor or pharmacist can help. TNF is a part of your immune system which can cause inflammation and damage. Simponi blocks TNF in your body. It can help improve conditions including Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis and Ulcerative Colitis. Simponi can lower your ability to fight infections. You should tell your doctor right away if you get an infection or open cuts or sores on your body. You should also call if you have a possible sign of infection, like a fever, cough or flu-like symptoms. As with any medicine, rare but serious side effects could occur. You should read the 'Medication Guide' to know what to watch for. In general, you should pay close attention to your body. Call your doctor right away if you notice any unusual changes. It's important to check with your doctor or pharmacist before taking other medicines, even if they don't require a prescription. Also, check before getting vaccines. You should keep Simponi in the original carton in the refrigerator, and you should not allow it to freeze. Before each dose, let it come to room temperature naturally. Also, inspect the medicine, and do not use it if it looks cloudy or if there are large or colored particles. For best results, continue Simponi as directed by your doctor because it can help improve your condition.